This curriculum provides a complete introduction to the principles and practice of renal pathology. It is geared particularly towards early-career professionals, clinicians working with renal patients.
Learning objectives:
1. Know the various techniques to assess a renal biopsy
2. Know and understand the technical procedures for identification, allocation, processing and staining the renal biopsy for light microscopy, immunofluorescence and electron microscopy.
3. Articulate the elementary mechanisms of glomerular injury
4. Recognize the structure of renal biopsy sections and identify deviations from normalcy
5. Properly evaluate the histologic, immunofluorescence, electron microscopic and clinical findings in the common medical diseases of the kidney
6. Synthesize information obtained from different modalities used renal biopsy examination together with clinical information to make a differential diagnosis
7. Understand pathologic elements of transplant rejection, and the most prominent pathologic lesions associated with anti-rejection medications
Turki Al-Hussain
Saudi Arabia
Pierre Ronco
France
Pierre Ronco, MD, PhD, is Professor of Nephrology at Sorbonne Université. He has devoted his career to the care of patients with glomerular disease and the identification of pathophysiological mechanisms and novel therapeutic strategy, particularly in the field of membranous nephropathy. He is an author of > 500 research publications (New England Journal of Medicine, The Lancet, Science, Nature Com.), and 30 chapters.He received the Jean Hamburger award (ISN), the prize for outstanding basic research (ERA) and an ERC advanced grant ; he is an ERA distinguished fellow, Honorary Member of the Japanese Society of Nephrology, and Doctor Honoris Causa of the UC Louvain University. He is a member of the Academia Europeae, the French Academy of Medicine and the Royal Academy of Medicine (Belgium).He served as President of the Francophone Society of Nephrology, President of the ERA congress in Paris in 2012 and 2022. He has been serving ISN for >30 years as Councilor, Program Chair of 4 WCNs (Madrid 1995, Milan 2009, Cape Town 2015, Mexico City 2017) and Associate Editor of Kidney International. He is currently Editor in Chief since 2018.
Sandrine Florquin
Netherlands
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Module 1: Introduction to Renal Biopsies
Approach to Renal Biopsy in the Era of Precision Medicine: value of the renal biopsy & technical recommendation Part 1
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Approach to Renal Biopsy in the Era of Precision Medicine: value of the renal biopsy & technical recommendation Part 2
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Approach to Renal Biopsy in the Era of Precision Medicine: interpretation
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Approach to Renal Biopsy in the Era of Precision Medicine: beyond the microscope
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QUIZ: Approach to Renal Biopsy in the Era of Precision Medicine
0 Question | 1 attempt | 0/0 points to pass
0 Question | 1 attempt | 0/0 points to pass
Approach to Renal Biopsy
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QUIZ: Approach to Renal Biopsy
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
Further Reading: Beyond the Microscope: interpreting renal biopsy findings in the era of precision medicine
Select the "American Physiological Society" button to begin. | 60 minutes
Select the "American Physiological Society" button to begin. | 60 minutes
Module 2: Renal Pathology and Nephrotic Syndrome
Approach to Glomerular Lesions
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QUIZ: Approach to Glomerular Lesions
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
Glomerular Diseases Causing Nephrotic Syndrome
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QUIZ: Glomerular Diseases Causing Nephrotic Syndrome
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
FSGS – The Latest
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QUIZ: FSGS – The Latest
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
Membranous Nephropathy – An Update
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QUIZ: Membranous Nephropathy – An Update
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
Further Reading: Diagnostic Pathology: Kidney Diseases
Select the "Diagnostic Pathology: Kidney Diseases" button to begin. | 60 minutes
Select the "Diagnostic Pathology: Kidney Diseases" button to begin. | 60 minutes
Module 3: Renal Pathology and Glomerulonephritis
Crescentic Glomerulonephritis Classification
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QUIZ: Crescentic Glomerulonephritis Classification
5 Questions | Unlimited attempts | 2/5 points to pass
5 Questions | Unlimited attempts | 2/5 points to pass
Glomerular Diseases Causing Glomerulonephritic Syndrome
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QUIZ: Glomerular Diseases Causing Glomerulonephritic Syndrome
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
IgAN Classification Update
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QUIZ: IgAN Classification Update
4 Questions | 1 attempt | 2/4 points to pass
4 Questions | 1 attempt | 2/4 points to pass
MPGN and C3 Glomerulopathies
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QUIZ: MPGN and C3 Glomerulopathies
4 Questions | 1 attempt | 2/4 points to pass
4 Questions | 1 attempt | 2/4 points to pass
Module 4: Transplant Pathology
The Transplant Kidney
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QUIZ: The Transplant Kidney
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
Drugs and the Kidney
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QUIZ: Drugs and the Kidney
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
Further Reading: Podocytes produced VEGF is essential for a good condition of glomerular endothelial cells. Disruption of VEGF signaling results in endothelial damage which is prerequisite for the development of TMA. TMA in these cases is almost exclusive
Select the "National Library of Medicine" button to begin. | 60 minutes
Select the "National Library of Medicine" button to begin. | 60 minutes
Further Reading: - The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials
Select the "National Library of Medicine" button to begin. | 60 minutes
Select the "National Library of Medicine" button to begin. | 60 minutes
Module 5: Pathology of Tubular and Tubulointerstitial Diseases
Hereditary Tubulointerstitial Diseases
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QUIZ: Hereditary Tubulointerstitial Diseases
3 Questions | Unlimited attempts | 2/3 points to pass
3 Questions | Unlimited attempts | 2/3 points to pass
QUIZ: Acute Tubular Injury - Morphologic Features Associated with Different Etiologies
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
Acute Tubular Injury - Morphologic Features Associated with Different Etiologies
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Module 6: Ren Path Quick Cases
25 Year Old With Fever and Allograft Dysfunction - Part 1
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25 Year Old With Fever and Allograft Dysfunction - Part 2
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Further Reading
Select the "Arkana Laboratories" button to begin. | 60 minutes
Select the "Arkana Laboratories" button to begin. | 60 minutes
46 Year Old Male With Early Allograft Dysfunction - Part 1
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46 Year Old Male With Early Allograft Dysfunction - Part 2
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QUIZ: 46 Year Old Male With Early Allograft Dysfunction
0 Question | 1 attempt | 0/0 points to pass
0 Question | 1 attempt | 0/0 points to pass
70 Year Old Diabetic Man - Part 1
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70 Year Old Diabetic Man - Part 2
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QUIZ: 70 Year Old Diabetic Man
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
25 Year Old Female With History of Lupus Nephritis - Part 1
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25 Year Old Female With History of Lupus Nephritis - Part 2
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QUIZ: 25 Year Old Female With History of Lupus Nephritis
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
Further Reading: Cell invasion in glomerular basement membrane: infolding glomerulopathy
Select the "PubMed" button to begin. | 60 minutes
Select the "PubMed" button to begin. | 60 minutes
A Patient With Positive ANA, dsDNA, and Low Complements
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QUIZ: A Patient With Positive ANA, dsDNA, and Low Complements
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
20 Year Old Man With New Diagnosis of SLE - Part 1
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20 Year Old Man With New Diagnosis of SLE - Part 2
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QUIZ: 20 Year Old Man With New Diagnosis of SLE
2 Questions | 1 attempt | 1/2 points to pass
2 Questions | 1 attempt | 1/2 points to pass
4 Year Old Male With Hematuria
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QUIZ: 4 Year Old Male With Hematuria
4 Questions | 1 attempt | 2/4 points to pass
4 Questions | 1 attempt | 2/4 points to pass
61 Year Old Man With AKI +ANA and +ANCA - Part 1
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61 Year Old Man With AKI +ANA and +ANCA - Part 2
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QUIZ: 61 Year Old Man With AKI +ANA and +ANCA
3 Questions | 1 attempt | 1/3 points to pass
3 Questions | 1 attempt | 1/3 points to pass
A 40-year Old Male With Proteinuria - Part 1
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A 40-year Old Male With Proteinuria - Part 2
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QUIZ: A 40-year Old Male With Proteinuria
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
24 Year old Female with Subnephrotic Range Proteinuria & amp; Normal Renal Function - Part 1
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24 Year old Female with Subnephrotic Range Proteinuria & amp; Normal Renal Function - Part 2
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QUIZ: 24 Year old Female with Subnephrotic Range Proteinuria & amp; Normal Renal Function
3 Questions | 1 attempt | 2/3 points to pass
3 Questions | 1 attempt | 2/3 points to pass
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